During 924 420.7 people?many years of follow?up (average pursue?upwards, 4.3 years; interquartile diversity, 2.6–5.step one ages), we noticed 1435 experience instances of CVD (occurrence rates, 16.0 for every ten 100 individual?years; Desk dos, Shape 2). From the completely adjusted model, the fresh multivariable?modified possibility rates (95% CIs) for CVD evaluating raised BP, stage 1 blood pressure levels, phase 2 blood pressure level, treated and you will purely managed blood pressure level, handled and you will regulated blood pressure level, treated and you can out of control blood circulation pressure, and you may unattended blood circulation pressure to normalcy BP (reference) were 1.37 (1.step onestep 1–1.68), step 1.forty-five (step one.26–step one.68), 2.twelve (step 1.74–2.58), step 1.41 (1.12–step one.78), 1.97 (step 1.5dos–2.56), 2.31 (step 1.56–3.37), and you may step one.93 (step 1.53–dos.45), correspondingly.
BP indicates blood pressure level; CVD, heart problems; DBP, diastolic BP; Hr, hazard proportion; SBP, systolic BP; TIA, transient ischemic assault.
Multivariable design try modified to own years, intercourse, cardiovascular system, season away from assessment examination, bmi, smoking status, alcoholic beverages consumption, exercise, academic height, total calorie consumption, reputation for diabetes mellitus, statin medication, Charlson comorbidity index, salt consumption, low?thickness lipoprotein cholesterol, high?occurrence lipoprotein cholesterol, triglyceride, and you can sugar
a Estimated of Cox proportional danger design. Multivariable design step 1 is adjusted to possess years, gender, heart, year off evaluation examination, bmi, puffing position, liquor consumption, exercise, informative peak, overall calories, history of diabetes mellitus, statin medication, Charlson comorbidity list, and you will sodium intake; design 2, design step one and additionally changes having low?occurrence lipoprotein cholesterol, high?density lipoprotein cholesterol, triglyceride, and you can sugar.
Shape 2. Growth of heart problems from the blood pressure level (BP) class. Estimated away from Cox proportional risk design. DBP indicates diastolic BP; SBP, systolic BP; TIA, transient ischemic attack.
The brand new totally modified issues rates (95% CIs) to own heart attack or transient ischemic assault comparing raised BP, phase step one blood pressure levels, stage dos blood pressure, treated and you will strictly controlled blood circulation pressure, addressed and you may managed blood pressure level, treated and you may uncontrolled hypertension, and untreated blood pressure level to normalcy BP (reference) was basically step 1.sixty (step 1.13–dos.27), step one.69 (1.31–2.17), 3.02 (2.21–4.step one3), 1.forty-five (0.96–2.20), step one.88 (step 1.15–3.09), step three.39 (1.84–6.23), and you can step one.64 (step one.03–dos.60), correspondingly. An excellent graded, progressive relationship anywhere between BP kinds has also been noticed having individual consequences (Dining table S1). The relationships was such as for example strong getting cerebrovascular outcomes.
The absolute incidence rates of CVD were lower in younger participants (incidence rates of 5.5, 20.2, and 54.4 for those aged <40, 40?<50, and ?50 years, respectively), but the relative association between BP categories and CVD outcomes was stronger in younger compared with older participants (P=0.006 for interaction; Table 3, Figure 3). Notably, among young adults aged <40 years, the highest risk of CVD was observed in those with a history of hypertension but without antihypertensive medication.
Table 3. Relationship Ranging from BP Classification and the Development of CVD of the Different Years Strata
P=0.006 for the overall interaction between age and BP categories for development of CVD all event (adjusted model). Incidence density (per 10 000 person?years): 5.5 for subjects with age <40 years, 20.2 for subjects with 40 years ? age <50 years, and 54.4 for subjects with age ?50 years. BP indicates blood pressure; CVD, cardiovascular disease; DBP, diastolic BP; HR, hazard ratio; SBP, systolic BP.
Multivariable model are modified to have decades, sex, center, 12 months out of screening examination, body mass index, puffing reputation, alcohol consumption, exercise, educational level, full calorie intake, history of diabetic issues mellitus, statin medication, Charlson comorbidity directory, salt consumption, low?thickness lipoprotein cholesterol levels, high?occurrence lipoprotein cholesterol, triglyceride, and glucose
a good Projected regarding Cox proportional threat design. Multivariable model 1 was adjusted getting decades, sex, center, 12 months out of evaluating examination, body mass index, puffing position, alcohol consumption, physical exercise, educational height, overall calorie consumption, reputation for all forms of diabetes mellitus, statin procedures, Charlson comorbidity index, and you can sodium intake; model aisle app dos, model step 1 plus adjustment to have reduced?occurrence lipoprotein cholesterol, high?density lipoprotein cholesterol, triglyceride, and you will glucose.
Figure 3. Relationship anywhere between blood pressure levels (BP) group in addition to growth of heart disease in subgroup from the decades. Estimated from Cox proportional issues design. DBP suggests diastolic BP; SBP, systolic BP.